GLYCEROL RESTORES THE P53 FUNCTION IN HUMAN LINGUAL CANCER CELLS BEARING MUTANT P53
نویسندگان
چکیده
منابع مشابه
Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53
BACKGROUND We have previously reported that glycerol acts as a chemical chaperone to restore the expression of WAF1 in some human cancer cell lines bearing mutant p53. Since the expression of WAF1 is up-regulated by activated wildtype p53, glycerol appears to restore wtp53 function. The aim of the present study is to examine the restoration of heat-induced p53-dependent apoptosis by glycerol in...
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Tumor suppressor p53 plays an essential role in protecting cells from malignant transformation by inducing cell-cycle arrest and apoptosis. Mutant p53 that is detected in more than 50% of cases of cancers loses its role in suppression of tumors but gains in oncogenic function. Strategies to convert mutant p53 into wild-type p53 have been suggested for cancer prevention and treatment, but they f...
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Experimental Therapeutics Program, Division of Medical Oncology, College of Physicians and Surgeons of Columbia University, Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, Department of Neurosurgery,Neurologic Institute of New York, Columbia University Medical Center, N.Y. 10032, Department of Chemistry, College of Staten Island, 2800 Victory...
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Evidence supporting a broad role for the inactivation of the p53 gene in human tumorigenesis has been provided by studies showing that the p53 gene is mutated in many human cancers. In this study, we report on the mutational status of the p53 gene in prostate cancer cells and provide functional evidence that the wild-type p53 gene may have a role in suppressing prostatic tumorigenesis. Sequence...
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ژورنال
عنوان ژورنال: Japanese jornal of Head and Neck Cancer
سال: 2001
ISSN: 1883-9878,0911-4335
DOI: 10.5981/jjhnc1974.27.639